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January 1958

Influence of Infection on Homografts and Synthetic (Teflon) Grafts: A Comparative Study in Experimental Animals

Author Affiliations

From the Research and Development Service, Fitzsimons Army Hospital, Denver.

AMA Arch Surg. 1958;76(1):67-73. doi:10.1001/archsurg.1958.01280190069013

It is occasionally necessary to replace segments of blood vessels lost due to disease, trauma, or congenital abnormalities in infected or contaminated wounds. Though good results have been obtained with homografts and a variety of synthetic materials as vascular prostheses in sterile wounds, it is quite conceivable that the proteolytic enzymes of infection would digest a homograft, and it has been demonstrated that a close weave of a synthetic material prevents healing of infected wounds in other portions of the body.1,5 The present report is based on a study in experimental animals undertaken to determine whether either graft is satisfactory, and, if so, which is preferable in the presence of contamination or infection.

Teflon (polytetrafluoroethylene) was chosen as the synthetic material because the results in a comparative series, including Dacron, nylon, Orlon, and Ivalon (polyvinyl formalinized) sponge, indicated that it was preferable for vascular prostheses, particularly when replacing segments

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