The diagnosis of radiation cancer is often difficult to verify, but certain neoplasms developing in tissues heavily irradiated 10 or more years previously might often be considered examples of this disease. Such is the status of the tabulated instances of radiation laryngopharyngeal cancer (Table). Goolden's monograph on this subject contains the statement that the original irradiated disease process must be benign for this diagnosis to be authenticated. Slaughter and Southwick18 have recently written on mucosal radiation carcinomas and include two plausible instances in which second neoplasms followed the prior irradiation of other malignant tumors. The case to be described demonstrates the occurrence of a second neoplasm following external irradiation of the first malignant lesion, the original disease process persisting at the time of the final therapy. As can be seen in the Table, all of the other reported radiation cancers of the laryngopharynx have developed in areas where benign disease previ
NELSON WR, MAYER AW. Presumed Radiation Carcinoma of the Tongue Base and Carcinoma of the Thyroid: Resection, with Tube Pedicle Repair; Report of a Case. AMA Arch Surg. 1958;76(4):611–616. doi:10.1001/archsurg.1958.01280220131027
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