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May 1958

Induction of Tolerance to Homografts by Nonspecific Pooled Blood

AMA Arch Surg. 1958;76(5):769-773. doi:10.1001/archsurg.1958.01280230109017

Induced tolerance to homografts obtained by embryonic injection of the host with cells of the future donor is a phenomenon which has received extensive attention since the first report on the subject was made by Billingham and associates1 in 1953. Until recently, such induced homograft tolerance was considered a highly individual-specific matter. In order to produce tolerance in a given individual, the evidence seemed to indicate that living cells from the individual future donor must be injected into the individual future host during the embryonic period of the host. Our recent studies of the homograft problem have dealt with induced tolerance in the chick. The technique of inducing tolerance between 10- to 16-day-old, incubated chick embryos has been described elsewhere2 (Fig. 1). The presence or absence of tolerance is tested by interchanging skin homografts between 1-day-old or 14-day-old chicks; this technique has also been described elsewhere.3