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June 1958

Homologous Marrow Transplantation in Rabbits After Triethylenethiophosphoramide

Author Affiliations

From the Laboratories for Surgical Research, Harvard Medical School and Peter Bent Brigham Hospital.; Joint British Postgraduate Medical Federation Travelling Fellow and George Gorham Peters Fellow (Dr. Porter); present address: Department of Pathology, St. Mary's Hospital, Paddington, London, W. 2. Associate in Surgery (Plastic Surgery) Peter Bent Brigham Hospital; Clinical Associate in Surgery, Harvard Medical School (Dr. Murray).

AMA Arch Surg. 1958;76(6):908-911. doi:10.1001/archsurg.1958.01280240066010

Triethylenethiophosphoramide ( T h i o-TEPA), the sulfur derivative of triethylenephosphoramide, has been found to be active in preventing metastases of rat mammary adenocarcinoma.1 Clinically, temporary regression of human breast carcinoma has also been obtained,2-4 this drug being one of the few so far discovered with a definite effect on malignant epithelial tumors. However, bone-marrow depression, especially in patients with osseous metastases, has been encountered as a serious toxic effect, limiting the dosage which can be employed.

When marrow aplasia occurs in animals after exposure of the whole body to x-rays, the process can be reversed in some instances by an intravenous injection of homologous myeloid cells, the depleted blood-forming tissues being colonized by cells derived from those which have been injected.5

The present experiments were therefore undertaken to determine whether homologous * marrow would similarly implant any proliferate when infused into rabbits which had received marrow-depressant doses of