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July 1958

Effects of Acid Administered Intragastrically on Gastric Acid in Man: Inhibitory Effect on Gastric Secretion of Acid in Response to Test Meal

Author Affiliations

Rochester, Minn.
Fellow in Surgery, Mayo Foundation (Dr. Schmidt). Section of Surgery, Mayo Clinic and Mayo Foundation (Dr. Hallenbeck). The Mayo Foundation, Rochester, Minn., is a part of the Graduate School of the University of Minnesota.

AMA Arch Surg. 1958;77(1):26-32. doi:10.1001/archsurg.1958.01290010028006

It has been recognized for many years that unneutralized gastric acid inhibits further secretion of acid by the stomach, thus providing an autoregulatory mechanism for control of secretion of acid. According to Babkin,1 Sokolov in Pavlov's laboratory, using dogs with gastric and duodenal fistulas and complete separation of stomach and duodenum, found that introduction of 0.5% solution of hydrochloric acid into the stomach or of gastric juice into the duodenum inhibited secretion from a Pavlov pouch. Subsequent studies have shown that acid instilled into the duodenum can inhibit the secretory response of Pavlov pouches to (1) the cephalic phase of gastric secretion induced by sham feeding,2 (2) the intestinal phase of gastric secretion induced by putting food into a duodenal fistula,2 (3) the feeding of a meal of meat,3,4 (4) the injection of histamine,3 and (5) the oral administration of ethanol.3 Code and Watkinson

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