It has been recognized for many years that unneutralized gastric acid inhibits further secretion of acid by the stomach, thus providing an autoregulatory mechanism for control of secretion of acid. According to Babkin,1 Sokolov in Pavlov's laboratory, using dogs with gastric and duodenal fistulas and complete separation of stomach and duodenum, found that introduction of 0.5% solution of hydrochloric acid into the stomach or of gastric juice into the duodenum inhibited secretion from a Pavlov pouch. Subsequent studies have shown that acid instilled into the duodenum can inhibit the secretory response of Pavlov pouches to (1) the cephalic phase of gastric secretion induced by sham feeding,2 (2) the intestinal phase of gastric secretion induced by putting food into a duodenal fistula,2 (3) the feeding of a meal of meat,3,4 (4) the injection of histamine,3 and (5) the oral administration of ethanol.3 Code and Watkinson
FERNAND R. SCHMIDT, GEORGE A. HALLENBECK. Effects of Acid Administered Intragastrically on Gastric Acid in ManInhibitory Effect on Gastric Secretion of Acid in Response to Test Meal. AMA Arch Surg. 1958;77(1):26–32. doi:10.1001/archsurg.1958.01290010028006
* * Maintenance Notice * *
Maintenance will be performed from 11:00pm CT December 16, 2017 to 4:00pm CT December 17. Please be advised that your site/services may be periodically unavailable during this maintenance window.