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July 1958

A Study of Cortical Oxygen Tension During Induced Hypotension: Electroencephalographic, Blood Pressure, and Blood Volume Correlations in Dogs During Hemorrhagic Hypotension With and Without Ganglionic Blocking Agents

Author Affiliations

Durham, N. C.
Present Address (Dr. Bloor): Cleveland City Hospital, Cleveland 9.; From the Departments of Neurosurgery, General Surgery, and Anesthesiology, Duke University Hospital, and Veterans' Administration Hospital.

AMA Arch Surg. 1958;77(1):65-74. doi:10.1001/archsurg.1958.01290010067012

In recent years the initial wave of enthusiasm for the use of induced hypotension by ganglionic blockade during certain surgical operations has been supplanted by a desire for a more careful appraisal of the technique.1-3 Clinical analyses of surgical patients subjected to hypotension have provided useful, but incomplete, information because of the many uncontrollable variables—in particular, the loss of blood during surgery. Although much work has been done on the various aspects of hemorrhagic hypotension or shock and the influence thereon of surgical or chemical sympathectomy, most of the interest has been directed toward visceral changes4,5 and survival rates in animals kept hypotensive by the techniques of Wiggers and Fine.6-10 Except for a few isolated instances,11-13 the relationship between the cerebral and the systemic hemodynamics has received very little attention, and little is known about the cerebral hemodynamic responses either to hemorrhagic hypotension, per se, or

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