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December 1958

Reaction of Dog Artery and Brain to Latex: Further Laboratory Studies Related to Surgery of Intracranial Aneurysms

AMA Arch Surg. 1958;77(6):974-979. doi:10.1001/archsurg.1958.01290050144027

In a previous study1 several plastic substances and natural latex were tested as agents that could be applied to blood vessels to promote fibrosis and thereby strengthen the vessel wall. Of these substances, natural Hevea latex seemed the most satisfactory. Because of its white color, even distribution over the entire surface could be assured under direct vision. With acidification of the vessel surface with 0.5% acetic acid, latex applied over the surface "set" in about two minutes. The inflammatory response and fibrosis from latex seemed to be of the desired intensity.

In the present series of animal experiments an attempt has been made to determine the feasibility of applying latex to the cerebral vessels of man. Tests were made (1) to observe further vessel thickening and perivascular fibrosis; (2) to determine the reaction of central nervous tissue to latex; (3) to observe handling properties of latex in the immediate