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January 1959

Reversal by Ipsilon of Lytic System in Blood Stream Produced in Rabbits by Streptokinase

AMA Arch Surg. 1959;78(1):33-36. doi:10.1001/archsurg.1959.04320010037006

Ipsilon (ε-amino-caproic acid) has been reported to have the ability to inhibit completely at a small concentration the activity of plasmin.3 The measurement of antiplasmin power in that investigation was studied by using fibrin clots.

The capacity of Ipsilon to inhibit a lytic system in the blood stream may have considerable promise in clinical medicine. The drug may provide a means of producing coagulation of the blood in patients whose clots undergo spontaneous lysis. Ipsilon might also serve as an antidote in patients who have had a lytic system established by streptokinase for the treatment of thrombosis. A conceivable extension of the use of streptokinase would be to produce an incoagulable blood in patients undergoing cardiac surgery when the heart-lung machine is used with the lytic system reversed by Ipsilon. The many clinical uses to which the drug could be put, particularly to inhibit the effects produced by streptokinase

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