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February 1959

Fate of Aortic Homografts in Experimental Canine Atherosclerosis: II. Study of Fresh Abdominal Aortic Implants into Abdominal Aorta

Author Affiliations

New York
From the Henry and Lucy Moses Research Laboratory of the Surgical Division, Montefiore Hospital, and the Pathology Department, Mount Sinai Hospital.

AMA Arch Surg. 1959;78(2):239-245. doi:10.1001/archsurg.1959.04320020061010

In a previous investigation1 it was shown that fresh homologous thoracic aortic implants into the abdominal aorta of dogs receiving a chronic atherogenic diet exhibited minimal or no atheromatous changes, while extensive lesions were found in the host abdominal aorta. It appeared from this study that fresh thoracic homografts showed far less susceptibility to atherosclerosis than the host abdominal aorta. These findings, coupled with our previous study showing a metabolic difference between thoracic and abdominal aorta in the dog,2,3 suggested the existence of a biologic dissimilarity between the two aortic segments.

To test this hypothesis further, another series of experiments was undertaken in which fresh abdominal aortic homografts were implanted into the abdominal aorta.

The present study is concerned with the fate of these grafts investigated by histological and biochemical methods.

Material and Methods  Fourteen mongrel dogs, ranging in age from 1 to 3 years and weighing between

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