Nonspecific granulomatous ileitis, as a distinct entity, was described for the first time by Crohn, Ginzburg, and Oppenheimer in 1932.1 References to this disease are made in the literature as far back as 1769, by Morgagni,2 and in 1913 by Dalziel,3 and in 1923 by Moshcowitz and Wilensky.4 The disease is not uncommon, with Marshak and Wolf5 reviewing 750 cases from the Mount Sinai Hospital in New York in 1955 and Van Patter, Bargen, et al.6 reporting on 600 cases from the Mayo Clinic in 1954. The incidence of malignancy in the small bowel in nonspecific granulomatous enteritis is extremely low. The first case reported was that of Ginzburg et al. in 1956,7 with an adenocarcinoma seen in the jejunum and multiple metastases to the liver. The inflammatory disease in the small bowel appeared to have been present for 15 years, from the
WEINGARTEN B, PARKER JG, CHAZEN EM, JACOBSON HG. Adenocarcinoma of the Jejunum in Nonspecific Granulomatous Enteritis. AMA Arch Surg. 1959;78(3):483–489. doi:https://doi.org/10.1001/archsurg.1959.04320030127021
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