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April 1959

Study of Revascularization of Autogenous Cortical Bone Grafts in Rabbit Using Radiophosphorus

Author Affiliations

From the Department of Orthopedic Surgery, University of Pittsburgh School of Medicine.

AMA Arch Surg. 1959;78(4):551-555. doi:10.1001/archsurg.1959.04320040047014

This study was undertaken in an attempt to evaluate the fate of various types of autogenous cortical grafts in the rabbit by a somewhat different method than those usually employed. The influence of the physical form of the graft is shown, as well as the deterrent effect of fibrous periosteum as a barrier to revascularization. The effect of using a motor-driven saw rather than a osteotome is also shown.

Cohen et al.3 have used Ca45 as an indicator of homogenous bone-graft fate. Kiehn et al.7 have used phosphorus for the purpose of comparing the incorporation of autogenous bone grafts into the host. Evaluation of bone grafts from a histological point of view have demonstrated the difficulty inherent in determining the end-point by this means. Each microtome section shows only a small part of the graft and host; the interpretation is often tedious and controversial. The uptake of

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