Although it is generally believed that malignant tumors in children are associated with a poorer prognosis than are malignancies in adults, the reasons for such an assumption, other than clinical observation, have not been made clear. Vascular dissemination of cancer in children may be of importance in this regard. This study is concerned with that aspect of the vascular dissemination dealing with the carriage of cancer cells in the circulating blood of children, and the occurrence of these cells during an operative procedure.
Since 1869, when Ashworth1 reported cells in the blood which appeared to be similar to the cells of the patient's multiple malignant skin tumors, several investigators2-4 have reported "abnormal cells" in the blood stream.In 1954 Cole, Packard, and Southwick,5 using the Papanicolaou slain, reported cancer cells in the fluid perfused through the major artery and collected from the vein of a
GROVE WJ, WATNE AA, JONASSON OM, ROBERTS SS. Vascular Dissemination of Cancer in Children. AMA Arch Surg. 1959;78(5):698–702. doi:10.1001/archsurg.1959.04320050030004
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