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September 1959

Familial Intestinal Polyposis

Author Affiliations

London, Ontario, Canada
From the Department of Surgery, University of Western Ontario.

AMA Arch Surg. 1959;79(3):393-398. doi:10.1001/archsurg.1959.04320090041006

Familial intestinal polyposis is a hereditary disease complex with a predilection to cancer of the colon or rectum at an early age. Saint1 made a clear distinction between this familial group, in which the polyps are adenomatous, and another group on the basis of glandular hyperplasia produced by inflammation or some form of local irritation.

The familial group has been studied intensively by Lockhart-Mummery,2 Lockhart-Mummery and Dukes,3 and Dukes,4 at St. Mark's Hospital in London, England. They believe the disease due to a gene mutation capable of producing an excessive proliferation of the glandular epithelium in the mucous membrane of the colon and rectum. It is not congenital but appears usually after 10 years of age. The polyps increase in number and size and may cause a blood-stained mucous diarrhea along with weight loss and anemia. The same mutation that produced the polyps can, as a

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