[Skip to Navigation]
November 1959

Effect of Intravenous Heparin on Terminal Temperature in the Hypothermic Dog

Author Affiliations

From the Halsted Laboratory of Experimental Surgery, University of Colorado School of Medicine.; Dr. Montgomery's work was done during the tenure of an Advanced Research Fellowship of the American Heart Association.

AMA Arch Surg. 1959;79(5):729-733. doi:10.1001/archsurg.1959.04320110031005

The terminal temperature of surfacecooled adult dogs is remarkably constant. If we define the terminal temperature as the rectal temperature at which a dog's heart succumbs either to ventricular fibrillation or to cardiac arrest, we find from the literature the following mean terminal temperatures: 16.5 C, DeBoer et al.1; 18.5 C, Covino et al.2; 18.6 C, Hegnauer,3 and in the present no-treatment group, 19.4 C. Young dogs withstand much lower temperatures. DeBoer1 found that the mean lethal temperature of young dogs was 9.5 C. The present paper describes experiments in which the mean terminal temperature of adult surface-cooled dogs was significantly reduced below those values reported above.

Caranna et al.4 have shown that survival of animals cooled to 25 C and subjected to intracardiac surgery is increased by the infusion of nutrients; therefore, we wished to determine whether a continuous infusion of 5% dextrose would