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December 1959

The Treatment of Cancer by Perfusion

Author Affiliations

New Orleans
Tulane University School of Medicine; Charity Hospital of Louisiana; Touro Infirmary; U.S. Public Health Service Hospital.

AMA Arch Surg. 1959;79(6):963-975. doi:10.1001/archsurg.1959.04320120105012


Technique  Figure 3Figure 4Figure 5Figure 6

Technique  Figure 7Figure 8Figure 9Figure 10

Metastatic Melanoma  Fig. 11.—Before perfusion.Fig. 12.—Two years after perfusion.

Case 1.  —A 77-year-old white man. In 1956 malignant melanoma removed from left foot, followed by groin dissection May, 1957: Appearance of multiple dermal metastases. June, 1957: Isolated perfusion with 120 mg. phenylalanine mustard (PAM) through common femoral artery.Fig. 13.—Original lesion.Fig. 14.—Metastasis, six weeks after perfusion.Fig. 15.—Metastasis, eight weeks after perfusion.

Melanoma  Figure 16

Case 2.  —1947: Small mole (malignant melanoma) removed from right medical lower leg. 1958: Local recurrence followed by multiple excisions. Treated with TSPA intra-arterially without improvement (Fig. 16, A). December, 1958: Common femoral artery perfusion with 130 mg. PAM (1.8 mg. per kilogram of body weight). January, 1959: Many lesions disappeared (Fig. 16, B).Figure 17

Case 3.  —1957: Malignant melanoma with extensive metastases

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