Clinical appreciation of the evolution of bone metastasis of breast and prostate cancer after ovariectomy-adrenalectomy is fundamentally based, in our routine practice, on two elements: the rate of calcium metabolism in blood and urine and the radiological picture. Both are subject to modifications which, in favorable conditions of time and cases of development, prove regression in neoplastic foci and resumption of bone recalcification processes.
There now exists substantial statistical evidence showing a more dramatic improvement in the osseous metastases after ovariectomy-adrenalectomy in patients affected with hormone-dependent cancer, compared with less striking regression in the skin metastasis, as well as lymphoglandular, brain, pleura, and lung metastasis.
This difference in the behavior of the tumor cells, according to their localization, makes it necessary to consider, in interpreting the mechanism of regression of the metastasis, the reaction and sensitivity of the binomial—neoplastic tissue and host—to these states of surgically induced hormonal imbalance, "disendocrinia."
RUFFO A. Physiopathology of Bone After Bilateral Adrenalectomy. AMA Arch Surg. 1960;80(1):172–177. doi:10.1001/archsurg.1960.01290180174022
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