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April 1960

The Correction of Acidosis with Tris(Hydroxymethyl) Aminomethane: Treatment of Metabolic Acidosis Mixed Respiratory and Metabolic Acidosis with Tris(Hydroxymethyl) Aminomethane

Author Affiliations

Knoxville, Tenn.
From the East Tennessee Tuberculosis Hospital and the Acuff Clinic. Supported by U.S. Public Health Service Grant No. H-2315 and the Acuff Clinic Foundation.

AMA Arch Surg. 1960;80(4):693-697. doi:10.1001/archsurg.1960.01290210161031

Nahas has reported extensively on a new buffer amine, tris(hydroxymethyl)aminomethane ("tris") in the treatment of respiratory acidosis.1,2 He has shown that a "normal" pH can be maintained in the presence of total carbon dioxide retention of one hour's duration in experimental dogs. These exhibit oxygen uptake, blood pressure, etc. The impression is given that this compound is a pure antirespiratory acidosis agent, but this is not the case. Nahas has indicated the following reaction:

Thus, "tris" is a reversible hydrogen ion acceptor and should form compounds with acids other than carbonic acid. Some of these combinations may, in fact, be more stable.

The purpose of this communication is to show that "tris" can be used to prevent or to correct true metabolic acidosis or mixed acidosis, and to suggest some possible advantages of extending studies to include a "tris" carbonate and lactate.

Materials and Methods  Mongrel dogs of 12