The clinical entity of fulminating peptic ulceration associated with gastric hypersecretion and non-beta islet-cell tumors of the pancreas was first described in 1955 by Zollinger and Ellison.1 Since the original report over 80 cases of the syndrome have been recorded.2 Many of the early cases were discovered only on autopsy. However, with an increased awareness of the possibility of the existence of the entity, the diagnosis has been entertained preoperatively, and operative search and removal of the offending islet-cell tumor has been more frequently carried out. The discovery and resection of the non-beta islet-cell tumors has resulted in a marked reduction of gastric hypersecretion and apparent cure of the ulcer diathesis in some patients. However, is a few, the removal of the tumor, as well as appropriate gastric surgery, has failed to terminate the unrelenting progress of severe gastrointestinal ulceration. The continuance of the fulminating ulcer diathesis has
GERBER BC, SHIELDS TW. Simultaneous Duodenal Carcinoid and Non-Beta Cell Tumors of the Pancreas: Two Tumors of High Ulcerogenic Potential. Arch Surg. 1960;81(3):379–388. doi:10.1001/archsurg.1960.01300030039006
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