The replacement of circulating blood volume has been, for a long time, the accepted therapy for shock due to loss of intravascular fluid. This concept is solidly based on principles established experimentally many years ago by Blalock2 and by Parsons and Phemister.13 However, efforts to assist in the maintenance of blood pressure by increasing the peripheral resistance have been increasingly common in recent years, particularly since the advent of pressor agents such as levarterenol and phenylephrine Neo-Synephrine. Objections have been raised to the production of normotensive pressures by this method, in the presence of hypovolemia, since the problem of maintaining blood flow through vital tissues is by no means assured.10 Thus Remington et al.14 reported that the use of levarterenol decreased the survival time of dogs subjected to hemorrhagic shock, while Langston and Guyton7 showed that levarterenol by its direct action on the kidney, decreased
SALTZ NJ. The Effect of Ganglionic Blockade on Survival After Tourniquet Shock. Arch Surg. 1960;81(4):618–623. doi:10.1001/archsurg.1960.01300040102019
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