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October 1960

Disposable Pump Oxygenator for Perfusion in Small Animals: Used in Perfusing Chemically Modified Antibodies

Author Affiliations

Hines, III.
From Medical Research Division, Veterans Administration Hospital, Hines, Ill.

Arch Surg. 1960;81(4):668-670. doi:10.1001/archsurg.1960.01300040152029

Two methods can be used for perfusing small animals. Either the heart and lung of a second animal can be used as pump and oxygenator or a small mechanical oxygenator can be used.

With a mechanical pump oxygenator, the liver, lung, and spleen can be excluded in the perfusion of an extremity, for example. The exclusion of these organs is particularly helpful for a study of the perfusion of colloids, since these organs can remove some colloids in a single passage of blood.1

For a research program on chemically modified antibodies for cancer therapy, antibody complexes with a variety of radioactive and nonradioactive colloids are being investigated. The cytotoxic colloids being used include the fissionable actinides and boron-10 for the neutron capture therapy of tumors2; β and γ emittors; magnetic particles such as iron oxide for inductive heating of tumors, and suitably insolubilized antimetabolites and chelating agents. In

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