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November 1960

Studies in Experimental Frostbite: The Effect of Cold Acclimatization upon Resistance to Local Cold Injury

Author Affiliations

From the Department of Surgery, Indiana University Medical Center, Indianapolis.

Arch Surg. 1960;81(5):817-823. doi:10.1001/archsurg.1960.01300050139025

It appears clear that by some process of "acclimatization," "accustomization," or "cultivation," humans can better withstand exposure to cold than would otherwise be possible.* There can also be no doubt that the same process permits persons to work manually in extreme cold with greater dexterity and work efficiency than would otherwise be possible.2 As one observes such persons working under these circumstances, one, in addition, gains the impression that they can handle with their bare hands extremely cold objects without evidence of the local cold injury that might be expected to result in nonacclimatized subjects. Animal experiments, such as those of Blair et al.,3 and of Sellers and his colleagues4 have demonstrated that cold-acclimatized animals can be subjected to low environmental temperatures with better chance of survival and avoidance of cold injury than controls. The present study was undertaken to learn whether cold-acclimatization would have any effect

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