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January 1961

Experimental Hemorrhage: V. The Relationship Between Arterial Blood Pressure and Plasma Dilution in Acute Hemorrhage

Author Affiliations

Traveling Fellow of the Rockefeller Foundation (Dr. Hataya).; This work was partially done during the tenure of an Advanced Research Fellowship of the American Heart Association (Dr. Montgomery).; From the Halsted Laboratory of Experimental Surgery and the Departments of Surgery and Medicine, University of Colorado School of Medicine, Denver, Colorado.

Arch Surg. 1961;82(1):49-55. doi:10.1001/archsurg.1961.01300070053007

In 1895 Starling1 stated, "There are, however, certain facts which have been known to physiologists for the past 50 years and which, to my mind, prove conclusively the absorption by the blood vessels of the fluid in the connective tissue spaces. If an animal be bled to a certain amount, the remaining blood very shortly afterwards is found to be more dilute than before. It contains less hemoglobin and blood corpuscles and relatively more plasma. The plasma is also more dilute than before, showing that the increase in volume of blood chiefly consists of added water and salts, or at any rate, a fluid which contains less protein than the plasma." Adolph and Lepore2 confirmed the occurrence of plasma dilution following acute hemorrhage and concluded it was primarily due to the fall in arterial pressure. Later Adolph, Gerbasi, and Lepore3 bled animals rapidly (20 to 35 cc/kg