The use of hypothermia in conjunction with a pump-oxygenator combines the benefits derived from the reduction of the metabolic demands of the tissues with the ability adequately to perfuse the entire organism after the heart ceases to function at temperatures below 25 C. Not only is a further reduction in body temperature permissible, but rewarming of the body can be easily accomplished.
The practicality of this combination was demonstrated experimentally by Gollan7 with the survival of animals cooled to 10 C by perfusion of the entire organism with cold and subsequently warm blood when using an oxygenator. Peirce,21 in animals in which the body temperature was reduced to 25 C by internal cooling and external rewarming, showed that this moderate reduction in body temperature permitted a low-flow perfusion which could satisfactorily meet the tissue demands. By this work it was also demonstrated that a temperature gradient existed within
NEVILLE WE, KAMEYA S, OZ M, BLOOR B, CLOWES GHA. Profound Hypothermia and Complete Circulation Interruption: Experimental and Clinical Physiological Observations. Arch Surg. 1961;82(1):108–119. doi:10.1001/archsurg.1961.01300070112014
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