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January 1961

Pathologic Changes in Experimental Hypothermia

Author Affiliations

From the Departments of Surgery and Pathology, University of Colorado Medical Center.

Arch Surg. 1961;82(1):147-152. doi:10.1001/archsurg.1961.01300070151018

Introduction  The pathologic changes due to hypothermia are generally believed to be minimal, although the literature on this subject is not extensive.1 There have not been any reports published on the pathologic changes following hypothermia of 9 to 18 C.Previous attempts in this laboratory to rewarm surface-cooled dogs from low temperatures (approx. 12 C) have been unsuccessful, and other investigators have had similar experiences.2,3 However, it was noticed that there were pathological changes in the cardiorespiratory systems of these animals, and their respirations were impaired by accumulations of copious amounts of fluid in the lungs.These observations stimulated our interest in the development of anatomical changes in other organs during the cooling period. In this experiment, therefore, detailed autopsies were done on each animal and gross and microscopic examinations made of all organs and tissues. During the cooling, various drugs and intravenous solutions were given to the