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February 1961

Electron-Irradiated Ox Fascia and Lyophilized Dura Mater: Tissue Reactions

Author Affiliations

From the Department of Surgery of The Johns Hopkins University School of Medicine.

Arch Surg. 1961;82(2):318-319. doi:10.1001/archsurg.1961.01300080146014

Electron-Beam-Irradiated Ox Fascia  When ox fascia was introduced some years ago,1,2 one of the great difficulties was its sterilization. It was impossible to remove it from animals in slaughter houses under aseptic conditions. Also it could not be heated without altering the collagen fibrils. It, therefore, had to be sterilized by chemical sterilization. It was found that an alcohol-acetone-aqueous solution of mercurochrome (Scott's solution) would do this satisfactorily. Laboratory tests showed that this solution would kill the spores of anthrax, tetanus, or gas bacillus in a comparatively short time. However, some quirk in the Federal law prevented the producers (Ethicon) from using this solution. It was then found difficult to find an adequate sterilizing solution which was not also irritant to the tissues, causing an unfavorable reaction when the material was implanted. Finally one was found which was fairly suitable, but even this solution had to be washed out

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