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March 1961

Gardner's Syndrome: Simultaneous Occurrence of Polyposis Coli, Osteomatosis, and Soft Tissue Tumors

Arch Surg. 1961;82(3):420-422. doi:10.1001/archsurg.1961.01300090090017

Diversity of clinical and pathologic manifestations is a notable characteristic of adenomatous polyps of the gastrointestinal tract. They may occur singly, by the dozen, or by the hundred, in any or all segments of the alimentary canal from the stomach to the rectum. They may produce obstruction, intussusception, hemorrhage, and other symptoms, or may be asymptomatic.

For many years polyposis coli has been considered worthy of identification as a clinical entity. Within the past decade the syndrome of gastrointestinal polyposis associated with pigmentation of the oral mucosa has been rediscovered, and, as a result of the repeated publication of individual case reports, is now a widely recognized entity. It should be emphasized that Peutz-Jeghers syndrome, an appropriate eponym for this condition, is not a variant of polyposis coli. It occurs at an earlier age, is a disease predominantly of the small intestine with an entirely different clinical pattern, and the