Most of the evidence for the association of host resistance factors to the development and progress of human malignant disease is indirect, and the mechanisms involved are poorly understood. The existence of such factors is suggested by these observations: (1) spontaneous regression of established tumors; (2) prolonged survival of patients after incomplete removal of their cancer; (3) the sudden appearance of widespread metastases many years after apparently successful treatment of the primary lesion; (4) regression of metastases after treatment of the primary tumor; (5) evidence that thousands and millions of tumor cells are exfoliated into the blood stream and lymphatics without the development of a comparable number of metastases; (6) histologic evidence of histiocytic and lymphocytic responses in the vicinity of some tumors and in the regional lymph nodes; (7) the appearance of antitumor antibodies in the serum of a few patients; (8) the development of hypersensitivity by certain patients
WATNE AL, MOORE GE, OLIVER RJ, KONDO T. Modification of Host Resistance to Malignant Cell Growth. Arch Surg. 1961;82(3):478–481. doi:10.1001/archsurg.1961.01300090148029
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