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April 1961

The Surgically Resected Gallbladder: A Morphologic Evaluation

Author Affiliations

Professor of Pathology, Albany Medical College.

Arch Surg. 1961;82(4):556-561. doi:10.1001/archsurg.1961.01300100070006

The surgically resected gallbladder is a difficult organ to evaluate because of the lack of clinicopathologic correlation. However, there is an increasing awareness of the high incidence of gallstones present in patients without significant clinical complaints.5 Approximately 5%-15% of patients with radiographically demonstrable gallbladder dysfunction and/or calculi prove to be clinically not benefited by cholecystectomy. Furthermore, the pathologist has long been cognizant of the high incidence of gallstones and chronic inflammation in the gallbladder observed incidentally at necropsy.9 In an effort to seek suitable criteria for evaluation, the pathologic alterations of the 178 gallbladders removed surgically at the Albany Hospital in 1954 were reviewed.

Of these specimens (145), 92% revealed chronic disease with calculi. These organs were first classified according to their gross features (Table 1).

After careful review of the histology, the most consistent anatomic change characteristic of significant chronic disease was observed in the mucosa. Two