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May 1961

Anaphylactic-Like Reactions: A Complicating Factor in Experimental Extracorporeal Circulation

Author Affiliations

Attending Surgeon, in Charge, Cardiovascular Surgery (Dr. Pratt).; From the Surgical Cardiovascular Research Laboratory, St. Vincent's Hospital.

Arch Surg. 1961;82(5):713-718. doi:10.1001/archsurg.1961.01300110075010

In a previous article, it was shown that marked splanchnic congestion, with uptake of blood from the extracorporeal circuit, usually occurred during experimental cardiopulmonary bypass perfusions.7 This paper presents our subsequent findings, showing that the above are part of an anaphylacticlike reaction to the homologous canine blood, used for priming the pump oxygenator. No red-cell isoagglutinins could be demonstrated, suggesting that the reactions were due to plasma incompatibility.

General Methods  The methods employed have already been described in detail.7 In brief, a Kay-Cross disk oxygenator and Sigmamotor pump were employed, with 100% oxygen as the oxygenating gas. The perfusions were carried out upon a scale in such a manner that an increase in weight represented the net transfer of blood from the extracorporeal circuit to the dog. Vascular pressures were monitored with U-tube manometers. Venous return was accomplished by gravity drainage. Crossmatching employed 2 drops of the recipient's