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June 1961

Age and Thyroid Carcinoma

Arch Surg. 1961;82(6):916-924. doi:10.1001/archsurg.1961.01300120130015

Carcinoma of the thyroid, uncommon in any age group, is one of the least common malignant neoplasms occurring in patients 14 years of age and younger. Dargeon reported 19 children with thyroid carcinoma seen during a 30-year period at the Memorial Hospital for Cancer and Allied Diseases.1 This is 1.5% of 1,248 cases of childhood cancer seen during this interval. In contrast, at the University of Iowa Hospitals, where many fewer patients with malignant neoplasms of all ages are seen, 15 children with thyroid carcinoma have been seen during a 10-year period. The finding that between 1 in 2 and 1 in 4 nontoxic nodular goiters occurring in children are carcinoma also suggests this lesion may occur more frequently than is commonly appreciated.2-5 The most authoritative statement on childhood thyroid carcinoma has been provided by Winship.2,6 His world-wide survey has yielded 571 cases.

The gross and microscopic