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December 1961

Clinical Appraisal of d-Pantothenyl Alcohol in Postoperative Ileus: A Double-Blind Study

Author Affiliations

From the Department of Surgery, The University of Texas, Southwestern Medical School, Dallas 35, Texas.

Arch Surg. 1961;83(6):916-920. doi:10.1001/archsurg.1961.01300180116022

Introduction  There have been numerous recent clinical reports praising the effectiveness of d-pantothenyl alcohol in shortening the period of postoperative ileus. In all of the early studies the drug was administered to a group of patients as the calcium salt or in alcohol form and results were described without adequate controls.1-8Recently, 2 studies have utilized the double-blind technique for clinical evaluation of the drug. Haycock et al.9 found a significant drop in the incidence of distention and earlier appearance of peristalsis in a group of 100 patients undergoing laparotomy for various reasons. Frazer et al.10 reported a series of 100 cases evaluated by the double-blind technique in which they found earlier resumption of audible peristalsis and passage of flatus in the treated group. No late ileus occurred in the 50 treated patients, but 6 cases of late ileus were observed in the control group. It was