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December 1961

The Use of Enzyme-Treated Heterografts as Segmental Arterial Substitutes: IV. Follow-Up Observations on Five-Year-Old Implants

Author Affiliations

From the Vascular Service, Middlesex General Hospital, and the Johnson and Johnson Research Foundation, New Brunswick.

Arch Surg. 1961;83(6):950-955. doi:10.1001/archsurg.1961.01300180150029

This paper constitutes a final report on a series of 41 dogs in whom abdominal aortic prostheses of enzyme-treated and untreated bovine carotid heterografts had been implanted. In earlier communications, the technique of preparation of the grafts,1 the physical properties of the collagen tubes prepared by enzymatic digestion,2 and the results of a 2½-year follow-up were presented.3

Sixteen dogs remaining after the last study survived to the time of killing, from 4 years and 2 months to 5 years and 2 months after grafting. Of these, 12 were grafted with ficin-treated bovine carotid arteries, and in 4, the undigested artery was implanted.

Since the initiation of this investigation, important changes have taken place in the concepts of segmental arterial replacement, both in the experimental and clinical fields. The abdominal aorta is no longer considered an adequate site to test arterial substitutes in the dog. It has been