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March 1962

Mechlorethamine Perfusion of the Isolated Canine Lung

Author Affiliations

From the Department of Surgery, Division of Thoracic Surgery Ohio State University Medical Center.

Arch Surg. 1962;84(3):337-343. doi:10.1001/archsurg.1962.01300210071015

Chemotherapeutic agents have been in use for some time for the treatment of neoplastic diseases. Klopp4 was the first to use them on a regional basis in 1950 in an attempt to provide a higher concentration of the drug in the region of the tumor. The main disadvantage of this method is that the drug perfuses through the organ or area and then returns to the general circulation, where it may cause severe toxic reactions in the patient. In 1958, Creech2 reported the successful use of an isolated-perfusion technique in which an extracorporeal circuit was employed to keep the drug completely separated from the general circulation. Limbs, pelvis, breast, and lungs have been perfused with various agents.2,3, 6-8 Several patients with inoperable bronchogenic carcinoma have had isolated perfusion of the lungs with mechlorethamine (nitrogen mustard).3 There is no report in the literature concerning the tissue response