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April 1962

Total Cerebral Ischemia in the Dog: Technique and Sequelae of Total Cerebral Ischemia

Author Affiliations

From the Department of Surgery, Stanford University School of Medicine.; Research Fellow, U.S. Public Health Service (Dr. Boyd); John and Mary R. Markle Scholar in Medical Science (Dr. Connolly).

Arch Surg. 1962;84(4):434-438. doi:10.1001/archsurg.1962.01300220058009

In a previous report1 we described a simple method of selectively cooling the brain as a possible method of allowing prolonged interruption of the cerebral circulation. It was apparent then that exact knowledge of the time tolerance of the brain to ischemia at various cerebral temperatures was needed if this technique was going to be applied clinically.

The dog was selected as our experimental animal because of practical considerations such as availability and ease of care. Initially we attempted to occlude the blood supply to the dog's brain by clamping the brachiocephalic and intercostal vessels. This attempt failed because of the open vertebral and spinal arteries. At this point we considered using the goat or rabbit because these animals receive the major portion of their cerebral circulation via the internal carotids, and thus, by occlusion of the carotids more nearly complete cerebral ischemia could be expected. However, even in

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