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April 1962

Anticoagulants and the Development of Pulmonary Metastases: Anticoagulant Effect on the Walker 256 Carcinosarcoma in Rats

Author Affiliations

From the Clotting Mechanisms Section of the Division of Experimental Surgery and Psysiology. Memorial-Sloan-Kettering Cancer Center.; Research Associate, Sloan-Kettering Institute (Dr. Agostino); Associate Professor of Clinical Surgery, Cornell University Medical College, and Associate Member, Sloan-Kettering Institute (Dr. Cliffton).

Arch Surg. 1962;84(4):449-453. doi:10.1001/archsurg.1962.01300220073012

Nearly 100 years ago, Ashworth2 reported the finding of cancer cells in the blood of a dead patient similar to those of the patient's malignant skin tumor. In 1934, Pool and Dunlop11 studied the systemic blood of patients with cancer for presence of neoplastic cells, and Engell5 in 1955 discovered tumor cells in the peripheral blood of patients with resectable and unresectable neoplasms.

In the last 4 to 5 years, because of the development of new cytologic methods, more reports have appeared in the literature on the presence of cancer cells in the blood of patients with resectable neoplasm. This led to the use of chemotherapeutic agents at the time of surgery in an attempt to affect the cancer cells in the systemic circulation.10,13

In our laboratory we have been investigating the effects of alteration of the clotting mechanism on the production of tumor metastases. Fibrinolysin