Wound healing, or tissue repair, is an integral part of the physiologic processes of all living matter. It is an expression of self-preservation of a part or the whole organism. Although the histologic alterations associated with injury and ensuing tissue repair may appear to be numerous, they represent variations on a limited number of histologic themes. These limited reparative mechanisms, varying somewhat with the organ or tissue, are dependent upon numerous locally and/or systemically active physiologic factors, among them the blood circulation, fluid and electrolyte dynamics, serum proteins (both qualitative and quantitative), oxygen supply, vitamin levels, infection,1-4 and perhaps many factors still unknown.The use of iproniazid in wound healing is empirical at present. In 1958, Bosworth5 reviewed his cumulative findings of the accelerated healing effects of orally or parenterally-administered iproniazid in tuberculous bony lesions and found that they compared favorably with wound healing in similar, nontuberculous
ROSENSTEIN IN, GOLDSTEIN HS. Refractory Wound Healing and Topically Applied Iproniazid Solution: A Preliminary Report of Fourteen Cases. Arch Surg. 1962;84(5):536–545. doi:10.1001/archsurg.1962.01300230052011
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