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May 1962

Refractory Wound Healing and Topically Applied Iproniazid Solution: A Preliminary Report of Fourteen Cases

Author Affiliations

Clinical Instructor, Department of Medicine, University of Miami School of Medicine; Consultant to Chest Clinic, Veterans Administration Hospital, Coral Gables (Dr. Rosenstein); Second-Year Resident, Department of Surgery, V.A. Hospital, Coral Gables (Dr. Goldstein).

Arch Surg. 1962;84(5):536-545. doi:10.1001/archsurg.1962.01300230052011

Introduction  Wound healing, or tissue repair, is an integral part of the physiologic processes of all living matter. It is an expression of self-preservation of a part or the whole organism. Although the histologic alterations associated with injury and ensuing tissue repair may appear to be numerous, they represent variations on a limited number of histologic themes. These limited reparative mechanisms, varying somewhat with the organ or tissue, are dependent upon numerous locally and/or systemically active physiologic factors, among them the blood circulation, fluid and electrolyte dynamics, serum proteins (both qualitative and quantitative), oxygen supply, vitamin levels, infection,1-4 and perhaps many factors still unknown.The use of iproniazid in wound healing is empirical at present. In 1958, Bosworth5 reviewed his cumulative findings of the accelerated healing effects of orally or parenterally-administered iproniazid in tuberculous bony lesions and found that they compared favorably with wound healing in similar, nontuberculous

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