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June 1962

The Collection and Preservation of Blood: Methods of Collection and Preservation and Suggested Procedures for Improving Its Quality for Massive Transfusions

Author Affiliations

The Department of Surgery, University of Colorado School of Medicine.

Arch Surg. 1962;84(6):599-607. doi:10.1001/archsurg.1962.01300240003001

Introduction  The clinical rationale for transfusing blood is to combat anemia or hypovolemia. When only moderate volumes are administered, the reactions which may ensue are caused by such features as immunologic incompatibility, allergenic factors, pyrogens, bacterial contamination, and late transmission of disease.36,71 In instances where copious quantities of blood are employed, as for massive replacement therapy, exchange transfusions, and priming of extracorporeal circuits, additional complications may result. These include bleeding tendencies, air embolism, pulmonary congestion from circulatory overload, transfusional siderosis, cardiac arrest or dysrhythmias, hepatogenic encephalopathy, and acid-base imbalance. The latter 3 sequelae are directly referable to the extracellular electrolyte moiety of the donor blood, and are also contingent on the metabolic status of the recipient.56To the end that patients may receive blood that is safe biochemically as well as in other properties, several techniques have been devised for collection and preservation. This paper reviews and analyzes

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