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July 1962

Duodenal Ulcer and Gastric Cancer

Author Affiliations

Presbyterian Hospital (Dr. R. B. Sawyer).

Arch Surg. 1962;85(1):109-114. doi:10.1001/archsurg.1962.01310010113015

The term "peptic ulcer" is used freely in relationship to both gastric and duodenal ulcers, but the ulcer in the stomach has clinical significance vastly different from that of the duodenal ulcer. A duodenal ulcer is considered primarily a benign medical disease, and it is associated with high gastric acid and peptic activity. The ulcer located in the stomach, however, has a definite malignant potential. It is often associated with normal or low gastric acidity, and is more frequently a surgical lesion. The coexistence of both gastric and duodenal ulcers ranges from 2.7% to 9%.10,11,13

The general interest in carcinoma of the stomach and its association with gastric ulcer is a source of constant discussion, but it is surprising how sparsely the literature is dotted with references to the coexistence of carcinoma of the stomach and duodenal ulcer. Bockus1 stated that "... patients with marked gastric hyperchlorhydria and hypersecretion

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