Homotransplanted canine livers can survive in recipient dogs for as long as 3 weeks.10,11 Evaluation of liver function and other tissue metabolism can be made during this time. Studies of this kind may lead to a better understanding of the homograft rejection mechanism.
Previous histological and biochemical studies in dogs following total homotransplantation of the liver have shown a marked proliferative cellular response in the organs and a progressive obstructive jaundice pattern in the blood. Total serum protein and albumin levels as well as albumin-globulin concentration showed no marked alterations as determined by ordinary laboratory methods.11 When paper electrophoretic analyses were done, a fall in albumin and a rise in α2-globulin were most characteristic.10 The availability of radioisotopic techniques for studying plasma protein metabolism prompted the present study with 2 objectives in mind: (1) to determine the rate at which the homotransplanted liver synthesizes individual
JOHN C. KUKRAL, MARK H. LITTLEJOHN, RICHARD K. WILLIAMS, RONALD J. PANCNER, GEORGE W. BUTZ, THOMAS E. STARZL. Hepatic Function After Canine Liver Transplantation. Arch Surg. 1962;85(1):157–165. doi:10.1001/archsurg.1962.01310010161022
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