Previous work in this laboratory has shown that the local application of acid-pepsin digested bovine tracheal cartilage microparticles will accelerate the healing of experimental wounds.1,2 This acceleration has been quantitated3 and characterized histologically.4 In addition, an experimental survey of a number of substances previously thought to have beneficial effects on the healing wound, and of compounds and substances prepared from cartilage, collagen, bone, or blood, revealed absolutely no beneficial results.5 Indeed, most of the effects were in a negative direction. This latter study was considered strong evidence for the specificity of the "cartilage effect." It indicated that an as yet unidentified, but specific, "repair-stimulating principle" was present in untreated cartilage. Furthermore, no such activity was found in such cartilage derivatives as chondromucoprotein or chondroitin sulfate.5
Following these studies on the properties of locally applied cartilage, the next step was to evaluate what, if any, effect could
PRUDDEN JF, INOUE T, OCAMPO L. Subcutaneous Cartilage Pellets: Their Effect on Wound Tensile Strength. Arch Surg. 1962;85(2):245–246. doi:10.1001/archsurg.1962.01310020075016
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