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October 1962

The Importance of Acid Inhibition in the Regulation of Gastric Secretion

Author Affiliations

Department of Surgery, University of Missouri School of Medicine.

Arch Surg. 1962;85(4):695-700. doi:10.1001/archsurg.1962.01310040167019

In recent years investigators have exhibited intense interest in the mechanisms involved in the inhibition of gastric secretion by acid in the gastric antrum and duodenum. Documentation of the existence of these acid inhibitory phenomena by innumerable experiments in animals as well as in man has led to the concept that the quantity and acidity of gastric juice secreted is determined not only by stimuli which act to increase gastric secretion but also by influences which tend to depress such secretion. Thus, the ingestion of food acts as a stimulant to the secretion of hydrochloric acid and pepsin until a low pH is reached within the stomach. This lowered intragastric pH inhibits further secretion by the stomach, either by blocking the release of the stimulatory hormone gastrin or, possibly, by initiating the release of a gastric inhibitory hormone from the antrum. If, in addition, the duodenal pH is also lowered,