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December 1962

Coronary Sinus Flow: Influence of Glucagon and Hypertonic Dextrose and Saline

Author Affiliations

From the Department of Surgery and the Heart Research Center, Indiana University School of Medicine, Indianapolis.

Arch Surg. 1962;85(6):879-881. doi:10.1001/archsurg.1962.01310060015004

The present study was undertaken in order to learn the effect of glucagon and of hypertonic dextrose and saline solutions upon coronary sinus blood flow.

Materials and Methods  Healthy mongrel dogs were anesthetized with intravenously administered thiopental sodium. The lungs were rhythmically insufflated with oxygen through a cuffed endotracheal tube, using a mechanical respirator. Mean blood pressures were measured through a plastic catheter in a femoral artery connected with a U-tube manometer. Midesophageal temperatures were determined with a telethermometer. The coronary sinus was catheterized with a No. 14 French catheter introduced through an external jugular vein. Coronary flow was measured in seconds required for 25 cc. of blood to accumulate in a burette according to a method previously described.1 Flows were first determined only after at least a 5 minute period of stabilization. Three determinations were then made at 5 minute intervals, expressed in cubic centimeters per kilogram per