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December 1962

Revascularization of the Dog Myocardium: 3. The Development of Collateral Blood Supply in the Dog Heart After Thrombosis of Synthetic Grafts

Author Affiliations

From the Department of Surgery, The Jefferson Medical College of Philadelphia.

Arch Surg. 1962;85(6):882-888. doi:10.1001/archsurg.1962.01310060018005

Arterial occlusion frequently occurs in humans in the proximal portion of the coronary arteries.1,2 If this portion of the artery can be bypassed, the myocardium can be supplied with blood through its distal ramifications. In previous experiments in this laboratory, when the internal mammary artery was anastomosed directly to the left circumflex coronary artery, incidence of thrombosis was high. Experiments were therefore devised in which synthetic grafts were interposed between the internal mammary artery and the circumflex coronary artery so that systemic arterial blood perfused the distal circumflex coronary artery.

Replacement of segments of blood vessels by synthetic grafts is a well-established procedure. The high velocity of blood flow tends to prevent thrombosis in grafts interposed in large vessels. Although the coronary arteries are small vessels, the velocity of flow is even greater than in the aorta. Therefore, it is possible that grafts interposed in these smaller vessels will

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