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December 1962

Response to Occlusion of the Portal Vein: Blood Pressure and Renal Blood Flow

Author Affiliations

From the Department of Surgery and the Heart Research Center, Indiana University School of Medicine.

Arch Surg. 1962;85(6):897-900. doi:10.1001/archsurg.1962.01310060033008

The present study was undertaken in order to investigate arterial blood pressure and renal blood flow responses to acute temporary occlusion of the portal vein and to compare them with those occurring with occlusion of the superior mesenteric vein and with occlusion of these 2 veins when combined with prior clamping of various visceral arteries.

Materials and Methods  Adult healthy dogs ranging in weight from 11.2 to 17 kg. were used. They were anesthetized by the intravenous injection of 5% thiopental sodium. Tracheal intubation was carried out, and adequate ventilation was maintained by administration of oxygen through a mechanical respirator. The vessels to be occluded were dissected free. The mean arterial blood pressure was determined by means of a U-tube mercury manometer connected with a plastic catheter inserted into the aorta through a femoral artery. Renal blood flow was determined by a direct method which has been described previously.1 Renal