The early diagnosis of gastric cancer has not as yet been accomplished. Although the incidence of gastric cancer has been found to be over 3 times greater than the expected national incidence if one restricts the group studied to achlorhydric patients over 50 years of age, it is clear that the standard gastrointestinal roentgenogram is capable of detecting these cancers only at a fairly advanced stage in their development. Among the gastric cancer patients treated at the University of Minnesota Hospitals, only 20.8% of 327 patients had a lesion localized to the stomach at the time of surgery.1 That the demonstration of gastric surface carcinoma is possible by exfoliative cytologic methods is made clear by Schade's experience in a large group of asymptomatic patients with negative x-ray and gastroscopic findings.2 In 2,500 Papanicolaou examinations of gastric washings, he found 25 cases of cancer not detected with other diagnostic
SCHEINER SL, DAVIS RE. Fluorescence Cytologic Screening: An Aid in the Diagnosis of Gastric Cancer. Arch Surg. 1962;85(6):948–954. doi:10.1001/archsurg.1962.01310060084017
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