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December 1962

Hypothermic Perfusion: Protection for the Ischemic Kidney

Author Affiliations

Presently at Strong Memorial Hospital, Rochester, New York (Dr. Matloff); Assistant Professor in Surgery, Yale University School of Medicine, and Attending Surgeon, Veterans Administration Hospital, West Haven (Dr. Gowen). Presently at Woman's Medical College of Pennsylvania, Philadelphia.

Arch Surg. 1962;85(6):999-1003. doi:10.1001/archsurg.1962.01310060135023

It is well documented that renal hypothermia prevents or modifies ischemic damage to the kidney.1-8 Regional renal hypothermia has been effectively achieved by surface-cooling techniques and also by intravascular perfusion of kidneys with hypothermic solutions. Although both methods have protected the ischemic kidney for periods up to 8 hours, intravascular perfusion offers the additional advantage of a more rapid and uniform cooling of the kidney without the danger of cortical necrosis that has been reported following the use of surface cooling.4,6

The present study deals with an intravascular technique for inducing regional renal hypothermia. Intrarenal temperature was reduced to the range of 14 to 16C during periods of renal ischemia by perfusing kidneys in situ with hypothermic, unoxygenated plasma. The effectiveness of this method was assessed by several indices of renal function including serial blood urea nitrogen (BUN) determinations, urinalyses, renal histology, and by survival of the animals.


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