[Skip to Navigation]
Sign In
January 1963

Perfusion Hypothermia Studies in Dogs: Cinefluorographic and Hemodynamic Studies

Author Affiliations

This work was completed during the tenure of a Postdoctoral Fellowship (Dr. Whalen), from the National Heart Institute, U.S. Public Health Service.; From the Departments of Medicine and Surgery, Duke Medical Center, Durham, and the Department of Pathology, Medical College of Virgina, Richmond.

Arch Surg. 1963;86(1):118-125. doi:10.1001/archsurg.1963.01310070120016

The large numbers of patients who have successfully undergone surgery utilizing various combinations of extracorporeal circulation and hypothermia testify to the efficacy of the combination of these techniques. The addition of hypothermia has led to lowered tissue metabolic demands, and thus, perfusion at relatively low flows or circulatory arrest has seemed practical. However, recent clinical reports1,2 and experimental studies3-5 suggest that hypothermia may not provide as large a margin of safety in preventing tissue damage when low-flow perfusion or circulatory arrest are used as had been previously hoped.

Recently Brown et al. reported their experience with combined deep hypothermia and extracorporeal circulation in dogs. These authors were particularly interested in the neurologic status and pathologic findings in dogs surviving perfusion. It was noted that a majority of dogs who survived low-flow perfusion with deep hypothermia developed a characteristic neurologic syndrome. The major features were hind leg weakness or

Add or change institution