Intra-arterial administration of chemotherapeutic agents is used by an increasing number of investigators as a means of obtaining a higher drug concentration in the tumor than in the remainder of the body. In contrast to the alkylating agents, antimetabolites have to be given over a period of at least several days in order to be effective.Sullivan first demonstrated, in 1958, that such treatment with methotrexate can be successful but that for optimal results 2 to 3 adequate courses of treatment are the minimum requirement. This implies that the intra-arterial catheter has to function properly for at least 6 weeks if not longer.In a report on 76 patients undergoing treatment through intra-arterial catheters, Duff et al. already noted complications such as bleeding, infection, or leakage, jeopardizing in a few cases even 1 adequate course of treatment. The nature of these complications suggested that they might arise more frequently
OETTGEN HF, DUFF JK, CLIFFORD P. Problems of Continuous Chemotherapy by Arterial Catheters. Arch Surg. 1963;86(2):323–330. doi:10.1001/archsurg.1963.01310080147033
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: