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March 1963

Renal Hypertension with Elevated Aldosterone: Case Due to Muscular Hypertrophy Cured by Nephrectomy with Decline of Aldosterone Levels to Normal

Author Affiliations

Departments of Surgery and Biochemistry, University of Mississippi Medical Center.

Arch Surg. 1963;86(3):374-377. doi:10.1001/archsurg.1963.01310090024004

It has been demonstrated that the experimental production of hypertension with renin may result in an increased production of aldosterone.1,2 Furthermore, it has been shown that patients with essential hypertension may exhibit an increased rate of aldosterone secretion.3 The purpose of this communication is to report a case which was instructive in several important respects. First, marked hypertension was associated with the widely recognized but still puzzling muscular hypertrophy of the renal artery.4,5 Second, whereas the pressure in the 2 uniformly small left renal arteries was equal to that in the aorta, the actual volume of flow was probably insufficient to perfuse adequately the small but histologically normal left kidney, resection of which completely abolished the hypertension. Third, a left adrenal vein blood sample taken during operation, just prior to the nephrectomy, revealed a markedly elevated aldosterone content that was statistically significant as compared with that of

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